SOL-Air: Environmental Factors and Diabetes Development in Latinos
The major goal of this project is to identify air pollution exposure among Visit 3 participants, including proposed physical activity monitoring by accelerometer in 300 Hispanic Community Healthy Study/Study of Latinos (HCHS/SOL) participants from four large metropolitan areas across the US. Project Number: R01ES030994
Funding Period: 09/22/2020 - 06/30/2026; Award PI: Joel Kaufman
Miami PI/Contact: Christina Cordero
Characterization of Sedentary Patterns and Cardiovascular Disease Risk Markers in Hispanic/Latinos (SOL-VIDA)
The major goal of this project is to investigate CVD-related outcomes and correlates of sedentary patterns in 2000 Hispanic Community Healthy Study/Study of Latinos (HCHS/SOL) participants from four large metropolitan areas across the US. This study will improve understanding of how sedentary time relates to cardiovascular disease risk in Hispanic/Latino adults. State of the art measures will be used to identify which aspects of sedentary time, including how sedentary time is accumulated, are most important to health. Findings will inform obesity, diabetes, and cardiovascular disease prevention efforts to improve population health. Project Number: R01HL148463
Funding Period: 07/17/2019 - 06/30/2026; Award PI: Jordan A. Carlson
Miami PI/Contact: Christina Cordero
Activity Levels, Myosteatosis and Insulin Resistance/Diabetes Mellitus
The major goal of this project is to study activity levels, Myosteatosis and insulin resistance/diabetes mellitus proposes to obtain CT scans of the abdomen and mid-thigh to measure skeletal muscle density and intermuscular adiposity (i.e., Myosteatosis), as well as visceral and hepatic adiposity from the abdominal CT scans.
Project Number: R01HL152790
Funding Period: 09/08/2021 - 06/30/2026; Award PI: Matthew A. Allison
Miami PI/Contact: Christina Cordero
Coronary Artery Calcium and its Association with Protection/Risk Factors and Epigenetic Patterns in Diverse US Hispanic/Latino Adults
The major goal of this project is to generate critical new data on the absence of subclinical atherosclerosis (assessed via coronary CT scan) in Hispanic/Latino adults from diverse ethnic backgrounds, and to examine relationships with potentially protective sociocultural factors specific to Hispanic/Latino populations, traditional CVD risk factors, lifestyle factors, and genetic and epigenetic patterns.
Project Number: R01HL152692
Funding Period: 06/01/2021 - 05/31/2026; Award PI: Martha Daviglus
Miami PI/Contact: Frank Penedo
Collaborative Cohort of Cohorts for COVID Research (C4R)
The adverse effects of COVID-19 on US health, economy, and society are widespread and deep. The Collaborative Cohort of Cohorts for COVID-19 Research (C4R) will leverage the deep phenotyping and genotyping of 15 US prospective cohort studies and ascertain all cases of COVID-19 infection by standardized questionnaire, events adjudication and serology to evaluate risk factors for infection and to track the prognosis of both those with and those without infection to address key short- and long-term questions on the COVID-19 pandemic across multiple research domains.
Funding Period: 03/01/2023 - 02/28/2026; Award PI: Elizabeth Oelsner
Miami PI/Contact: Maria Llabre
Arterial stiffness, brain morphology, cognition, and dementia in U.S. Hispanic/Latinos (Pulse Wave Velocity)
The major goal of this project is to assess modifiable risk factors for cerebral small vessel disease, cognitive decline, and Alzheimer’s disease and related dementias.
Project Number: R01AG061088
Funding Period: 02/15/2019 - 11/30/2025; Award PI: Michelle Meyer
Miami PI/Contact: Christina Cordero
Non-Alcoholic Fatty Liver Disease and Cardiovascular Disease in Hispanic/Latinos (NAFLD-CVD)
There is evidence that Hispanics/Latinos may have more fatty liver disease than other ethnic groups, and that their burden of heart disease is underappreciated. This study will evaluate environmental and/or genetic influences on these disorders, assess their interrelationship, and provide information to improve the heart and liver health of this vulnerable population.
Project Number: R01HL144707
Funding Period: 09/01/2019 - 08/31/2025; Award PI: Jorge Kizer
Miami PI/Contact: Christina Cordero
Study of Latinos (SOL) Ojos
The major goal of this project is to assess eye data collected in standardized data collection methodologies to establish a novel eye cohort linked with systemic disease data.
Project Number: UG1EY030410
Funding Period: 09/01/19-07/31/25; Award PI: Charlotte Joslin
Miami PI/Contact: David Lee
Pre-conceptional health of Latinas and its association with child adiposity (FLOR)
The purpose of this study is to investigate food reward-related behaviors and psychological stress as predictors of change in women’s cardiometabolic health and to identify early modifiable determinants of weight gain and adiposity development among children that are not attributable to the genetic environment. Participants in the study will be women currently enrolled in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), of reproductive age (18-44) at the time of their Visit 2 assessment. Project Number: R01DK116028
Funding Period: 08/06/2021 - 06/30/2025; Award PI: Daniela Sotres-Alvarez
Miami PI/Contact: Alan Delameter/Christina Cordero
Neighborhood Greenness and Cardiometabolic Health among Hispanics in the HCHS/SOL Study (SOL GREENNESS)
To improve our understanding of greenness’ cardiometabolic health impacts among Hispanics/Latinos, a growing and understudied population, at risk for the metabolic syndrome (MetS), diabetes and hypertension. Project Number: R01HL148880
Funding Period: 07/01/2020 - 06/30/2025; Award PI: Scott Brown
Miami PI/Contact: Scott Brown
Cardiovascular Health of Sexual and Gender Minorities in the Hispanic Community Health Study/Study of Latinos (SGM HCHS/SOL)
The cardiovascular health of Hispanic/Latino sexual and gender minorities has been understudied. The goal of this study is to examine relationships between sexual/gender minority stress, coping, social support, and heart disease - a leading cause of morbidity and mortality among Hispanic/Latinos in the U.S. Findings will inform development of culturally-appropriate interventions to address psychosocial factors that may contribute to cardiovascular health disparities by sexual orientation and gender identity. Project Number: R01HL149778
Funding Period: 03/04/2020 - 02/28/2025; Award PI: Tonia C. Poteat
Miami PI/Contact: Audrey Harkness
PASOS: Peripheral Artery Disease Study of SOL. An Ancillary Study of the Hispanic Community Health Study/ Study of Latinos
The major goal of this project is to address the hypothesis that PAD will be identifiable by suboptimal usual activity patterns of activity. The study will determine the prognostic value of 7-day physical activity, above and beyond self-reported leg symptoms and clinic-based physical function, to predict PAD-associated major health outcomes.
Project Number: R01HL146132
Funding Period: 08/01/2019 - 07/31/2024; Award PI: Robert Kaplan
Miami PI/Contact: Christina Cordero
Epidemiology of the Gut Microbiome, Pre-Diabetes and Diabetes in Latinos (GOLD 1 and 2)
The GOLD study will help us understand the role of the gut microbiome (GMB) on health. GMB (fecal) specimen will be collected at a single time point, which will be appropriate based on the observations that a GMB sample is representative of an individual’s core GMB and is stable for years if not decades. A brief questionnaire (GLQ) will record information about medication use, diet and medical history.
Project Number: R01MD011389
Funding Period: 07/08/2016 - 02/29/2024; Award PI: Robert Kaplan
Miami PI/Contact: Christina Cordero
Cardio-metabolic Outcomes in Multi-ethnic Physical Activity & Sedentary Behavior Study (COMPASS)
The purpose of the Cardio-metabolic outcomes in Multi-ethnic Physical Activity & Sedentary Behavior Study (COMPASS) will be to identify the association of physical activity and sedentary behavior with cardio-metabolic risk in participants with prediabetes enrolled in the Hispanic Community Health Study.
Project Number: R01HL136266
Funding Period: 12/15/16-11/30/23; Award PI: Yasmin Mossavar-Rahmani
Epidemiologic Determinant of Cardiac Structure and Function Among Hispanics (ECHO SOL 1 & 2)
This study conducted echocardiographic examination of a subsample of 1,800 Hispanic adults from HCHS-SOL to determine a population-based estimate of the prevalence of abnormal systolic and diastolic cardiac function in Hispanic adults, the degree of heterogeneity between Hispanic subgroups in cardiac function, and to establish the relationship of determinants particularly relevant to the Hispanic population (diabetes biomarkers and psychosocial / socioeconomic factors) to cardiac structure and function.
Project Number: R01HL104199
Funding Period: 09/01/2011-06/30/2022; Award PI: Carlos Rodriguez
Miami PI/Contact: Barry Hurwitz
HCHS/SOL Investigation of Neurocognitive Aging, MRI Study (INCA-SOL MRI)
The dual purposes of the study are to assess the impact of vascular risk factors and genetics on brain structure and function. MRI without contrast is used. Following the MRI assessments a clinical evaluation is conducted.
Project Number: 1RF1AG054548
Funding Period: 7/15/17-6/30/22; Award PI: Charles DiCarli
Miami PI/Contact: Christina Cordero
Persistent Organic Pollutants, Endogenous Hormones and Diabetes in Latinos
The purpose of this study is to analyze serum hormones, a measure of immune function and plasma levels of persistent organic pollutants (POPs) from blood already stored from the baseline HCHS/SOL study and relate those measurements to the incidence of diabetes, prediabetes, insulin resistance and a measure of pancreatic function in the 6-year follow-up, Visit 2, examination.
Project Number: R01ES025159
Funding Period: 06/01/16-05/31/22; Award PI: Victoria Persky
Study of Latinos – Investigation of Neurocognitive Aging (SOL-INCA)
This study is designed to repeat neurocognitive tasks previously administered 6 years before at baseline to assess neurocognitive decline and disorders in Hispanics/Latinos in HCHS/SOL and examine CVD and genetic risk factors that are associated with neurocognitive decline and development or disorders.
Project Number: R01AG048642
Funding Period: 09/1/15-04/30/20; Award PI: Hector Gonzalez
Hispanic Community Children's Health Study of Latino Youth SOL-Youth
This study measured 1,600 boys and girls ages 8-14 years, whose parent/ legal guardian completed the core components of the HCHS/SOL study. A comprehensive assessment of health determinants was administered.
Project Number: R01HL102130
Funding Period: 12/01/2012-11/30/2016; Award PI: Shrikant Bangdiwala
Miami PI/Contact: Alan Delameter
VISION: Ocular Healthcare Utilization and Ocular Risk in Hispanics
This study determined the prevalence of visual disorders and risk factors for vision disorders and assessed ocular healthcare utilization and knowledge of recommended ocular healthcare visits and risk factors for the development of visual disorders.
Project Number: IU58DP002652
Funding Period: 09/30/2010 - 09/29/2016; Award PI: David Lee
Miami PI/ Contact: David Lee
Study of Latinos: Nutrition & Physical Activity Assessment Study (SOLNAS)
This study (1) obtained objective biomarker measures of total and resting energy expenditure and of protein, sodium and potassium expenditure, (2) compared these biomarkers with energy and protein data from the 24- hr dietary recall, and (3) used these data to calibrate self-reported nutrient and physical activity data to increase reliability of analyses on associations with outcomes.
Project Number: R01HL095856
Funding Period: 04/25/2010-03/31/2016; Award PI: Yasmin Mossavar-Rahmani
Sleep Patterns as a risk factor for disease in the Hispanic Community Health Stud (SUEÑO)
This study (1) determined the prevalence of abnormal sleep patterns among Hispanic/Latinos, (2) examined the association between sleep-related factors with chronic disease risk factors and outcomes, and (3) assessed the role of poor sleep in mediating the effect of SES, demographic, and psychiatric factors on adverse health outcomes.
Project Number: R01HL098297
Funding Period: 06/01/2010-04/30/2015; Award PI: Sanjay Patel
Miami PI/Contact: Alberto Ramos
Sociocultural Factors and CVD risk/prevalence in Hispanics (SCAS)
This study involved administration of a comprehensive battery of socioeconomic, cultural, and psychosocial measures to help achieve HCHS/SOL goals of understanding how such processes may contribute to CVD risks and outcomes in the Hispanic population.
Project Number: RC2HL101649
Funding Period: 09/30/2009-06/31/2012; Award PI: Linda Gallo
Miami PI/Contact: Frank Penedo/Maria Llabre
