Center for Psycho-Oncology Research (CPOR)
Michael H. Antoni, Ph.D. Director
The Department of Psychology was awarded an NCI "Center" or P50 grant to study the effects of psychosocial intervention on quality of life and health variables in patients diagnosed with or at risk for different forms of cancer. This is a 5-year Center for Psycho-Oncology Research (CPOR) grant to conduct behavioral, psychological, social, and biomedical research on the interrelationships among cognition, emotion, biological processes, and physical health in patients with different forms of cancer including women with breast cancer, older men with prostate cancer, and women at high risk for cervical cancer due to co-infection with Human Immunodeficiency Virus (HIV+) and Human Papillomavirus (HPV+). Our prior work has shown that cognitive behavioral stress management (CBSM) intervention can improve mood, change cognitions and build coping resources; modulate the output of sympathetic nervous system, Hypothalamic Pituitary Adrenal, and Hypothalamic Pituitary Gonadal hormones; and normalize immunologic status in different populations. It remains to be determined whether these effects may generalize to patients with certain types of cancer and whether these psychosocial and physiologic changes influence quality of life and physical health in cancer patients. The proposed Center will directly address these issues through four randomized clinical trials. Each will (a) evaluate the effects of CBSM intervention on psychological distress, quality of life and disease status; and (b) examine the putative psycho-biological mediators (psychosocial, endocrine, and immunologic changes) of intervention effects observed. The Center will also support and conduct pilot studies of interventions in men and women with other cancers, and will also develop and test other forms of intervention as well as Spanish translations of CBSM for Spanish-speaking Breast and Prostate cancer patients.
- Coping After Treatment
- Cognitive Behavioral Stress Management and Cervical Neoplasia in HIV Infection
- Cognitive Behavioral Stress Management in Women with Breast Cancer
- Cognitive Behavioral Stress Management and Prostate Cancer
- Effects of Estrogen Therapy in Men with Metastic Prostate Cancer