Frank J. Penedo
Frank J. Penedo, Ph.D.
Associate Professor of Psychology University of Miami, 1999
- Research Interests
- Psycho-oncology, HIV and psychoneuroimmunology; psychology of aging and immunosenescence in chronically ill older adults; stress, coping, and personality styles in chronic illness.
Research Interests
My research is primarily focused on evaluating the efficacy of group- and individual-based stress management interventions on reducing distress, and improving quality of life and physical health among older adults (> 50 yrs.) with chronic illnesses such as Cancer and HIV. I am particularly interested in how psychosocial factors such as stress, coping and personality style may interact with health behaviors (e.g., treatment adherence), neuroendocrine function and the age-related decrements in immune function (i.e., immunosenescence) seen in older populations. More specifically, I am interested in how stress and other psychosocial factors may interact with, and exacerbate, age-related decrements in immune function that may promote disease progression in Cancer and HIV.
Center for Psycho-Oncology Research
Currently, I co-lead a project in our Center for Psycho-Oncology Research evaluating the effects of Cognitive Behavioral Stress Management in Prostate Cancer. In this project, together with a team of clinical researchers, I am evaluating to what extent can a psychosocial intervention reduce distress and improve quality of life and physical health in older men who have been treated for Prostate Cancer. I am particularly interested in how intervention-associated changes in several domains (e.g., coping, distress) can promote better quality of life and health status via neuroendocrine (e.g., stress hormones) and immune (e.g., natural killer cell cytotoxicity) pathways. Additionally, I am also leading a study that culturally and linguistically translates this project for Spanish speaking men with Prostate Cancer.
Sylvester Comprehensive Cancer Center
My other projects in the area of Cancer and older populations include a longitudinal study examining the psychosocial correlates of adjustment, quality of life and physical health among men and women recently diagnosed with Head and Neck Cancer. Participants in this study complete psychosocial (e.g., distress, coping, personality) and physical health measures immediately following diagnosis and three months after completing treatment (e.g., surgery, radiation).
Redes en Acción
Special Population Network for Cancer in Hispanic/Latinos
I am also principal investigator for the Southeast U.S. region of the National Cancer Institute--Special Population Network for Cancer in Hispanic/Latinos. Redes en Acción (Networks in Action: National Hispanic/Latino Cancer Network) is a National Cancer Institute (NCI) funded program that focuses on promoting Cancer research, training, and awareness. Redes brings together communities, organizations and individuals in national, regional, state, community, and academic networks to promote cancer control and prevention training, research, and awareness activities targeting the Hispanic/Latino population in the United States. The Southeast Region consists of Florida, South Carolina, North Carolina, Georgia, Puerto Rico, and the US Virgin Islands. The major aims of the Redes SPN are:
- To develop and maintain a network of individuals, cancer research centers, community-based organizations, and federal partners to foster a national infrastructure for cancer training, research, and awareness activities.
- To establish training and research opportunities for Hispanic/Latino students and researchers.
- To develop pilot projects into full competing grant applications.
- To continually support cancer awareness activities.
HIV Program Project
In addition to Cancer research, I am actively involved in our HIV Program Project. I currently lead a stress management intervention study designed to reduce distress and sustain or improve medication adherence and promote better physical health status among HIV+ heterosexual men with or without a history of drug use. Within our overall HIV projects, I lead a NIA-funded study evaluating age-differences in psychosocial and immune (e.g., naÏve/memory T-lymphocytes, pro-inflammatory cytokines) parameters among HIV+ men and women of various ethnicities and self-identified sexual orientations.
Ovarian Cancer Study
In collaboration with the University of Iowa (Dr. Susan Lutgendorf, PI), we are involved in study is funded by the National Cancer Institute designed to better understand the relationships between behavioral factors, hormones and cytokines including tumor growth factors such as VEGF in women newly diagnosed and treated for ovarian cancer. This study will provide a better understanding of how psychosocial factors such as social support and stress may buffer or promote disease processes via endocrine and immune mechanisms.
HIV Aging Reactivity Study
Rates of HIV infection among older adults are on the rise and this population typically presents with more advanced disease and are at greater risk for progression. Several lines of evidence suggest that a combination of psychological stress and age-related decrements in the immune system of older adults (immunosenescence) may be related to faster HIV disease progression. In this study, we are looking at the effects of a brief psychological stressor (a short speech) on immune messengers (cytokines) in older adults living with HIV. Specifically, we are looking at the cytokines IL-6, TNF-alpha and IL-10 and their interactions with epinephrine and norepinephrine before and after the speech stressor. By doing so, we hope to elucidate the links between psychological stress and HIV disease progression in older adults.
Selected Publications
Books and Monographs
Antoni, M. H., Schneiderman, N. & Penedo, F. J. (In Press). Behavioral interventions and Psychoneuroimmunology. In R. Ader, R. Glaser, N. Cohen, & M. Irwin (Eds), Psychoneuroimmunology (4th Ed). NY: Academic.
Penedo, F. J. & Dahn, J. R. (2005). Psychoneuroimmunology and Ageing. In K. Vedhara & M. Irwin (Eds.), Human Psychoneuroimmunology (pp.81-106). Oxford, UK: Oxford University Press.
Pereira, D. B. & Penedo, F. J. (2005). Psychoneuroimmunology and chronic viral infection: HIV infection. In K. Vedhara & M. Irwin (Eds.), Human Psychoneuroimmunology (pp. 165-194). Oxford, UK: Oxford University Press.
Cruess, D., Schneiderman, N., Antoni, M. H., & Penedo, F. J. (2004). Biobehavioral bases of disease processes. In T. J. Boll, R.G. Frank, A. Baum, et al. (Ed.), Handbook of Clinical Health Psychology: Models and Perspectives in Health Psychology (3rd ed.) (pp. 31-79). Washington, D. C.: American Psychological Association.
Ramirez, A., Perez-Stable, E. Medrano, M. A., Talavera, G. A., Marti, J. R., Giachello, A. J., & Penedo, F. J. (2004, March 1). Latino Cancer Report. Summary Recommendations for a National Hispanic/Latino Cancer Control Agenda. Redes en Accion: The National Hispanic/Latino Cancer Network. Retrieved from http://www.redesenaccion.org/publications/LatinoCancerRptSummary.pdf.
Ireland, S. J., Malow, R. M., Penedo, F. J., Roatta, V. G., Alberga, L., & Alferi, A. M. (1996). Predictors of HIV risk behavior among drug-dependent African-American women. NIDA Research Monograph, 162, 126.
Ireland, S., Malow, R. M., Alberga, L., Penedo, F. J., & Lewis, J. (1995). A test of the AIDS risk reduction model with indigent, cocaine abusing women. NIDA Research Monograph, 153, 54.
Malow, R. M., Ireland, S. J., & Penedo, F. J. (1995). Psychosocial correlates of HIV risk among pregnant drug abusers. NIDA Research Monograph, 153, 51.
Juried or Refereed Journal Articles
Gonzalez, J. S., Penedo, F. J., Llabre, M. M., Durán, R. E., Antoni, M. H. & Schneiderman, N. (Under Review). Physical symptoms, beliefs about medications, negative mood, and long-term HIV medication adherence. Annals of Behavioral Medicine.
Molton, I., Penedo, F. J., Dahn, J. R., Kinsinger, D., Gonzalez, J., Carver, C., Antoni, M. & Schneiderman, N. (Under Review). Personality dysfunction in older men recovering from prostate cancer: Doctor-patient communication, treatment satisfaction, and efficacy of a group-based intervention in promoting sexual function.
Carmack Taylor, C. L., Kulik, J., Badr, H., Smith, M., Basen-Engquist, K., deMoor, C., Penedo, F. J., & Griz, E. R. (Under Review). A social comparison theory of analysis of group composition and efficacy of cancer support group programs. Psychological Bulletin.
Molton, I., Penedo, F. J., Dahn, J. R., Schneiderman, N., & Antoni, M. H. (Under Review). Self-reported non-distress in older men with prostate cancer: Considering self-deception and impression management. Journal of Applied and Social Psychology.
Weaver, K., Llabre, M., Lechner, S., Penedo, F. J., Schneiderman, N., & Antoni, M. H. (Under Review). Comparing unidimensional and multidimentional models of benefit-finding in breast cancer. Journal of Consulting and Clinical Psychology.
Thomas, G. R., Penedo, F. J., Dahn, J. R., Traeger, L. N., Hernandez, M., Wen, J., Raynor, T., Fisher, P., Gachupin-Garcia, A., & Goodwin, W. J. (Undergoing Revisions). Coping styles and T cell immunity in patients with head and neck squamous carcinoma: preliminary results of a longitudinal study. Head & Neck.
Penedo, F. J., Traeger, L., Dahn, J., Molton, I., Schneiderman, N., & Antoni, M. H. (In Press). Cognitive Behavioral Stress Management Intervention Improves Quality of Life in Spanish Monolingual Hispanic Men Treated for Localized Prostate Cancer: Effects of a Randomized Controlled Trial. International Journal of Behavioral Medicine.
Siegel, S. D., Molton, I., Penedo, F. J., Llabre, M. M., Kinsinger, D. P., Traeger, L., Schneiderman, N. & Antoni, M. H. (In Press). Interpersonal sensitivity, partner support, patient-physician communication, and sexual functioning in men recovering from prostate carcinoma. Journal of Personality Assessment.
Remor, E., Penedo, F. J., Shen, B., Carrobles, J., & Schneiderman, N. (2006). Perceived stress as a predictor of CD4 cell count decline in men and women living with HIV/AIDS in Spain. AIDS Care PreEview. Published online. Retrieved from http://journalsonline.tandf.co.uk/media/chbdh0p6rm3tqpbfva6q/contributions/v/1/m/6/v1m6r36qn3648710.pdf
Carrico, A., Antoni, M. H., Duran, R., Ironson, G., Penedo, F. J., Fletcher, M. A., Klimas, N., Spitzer, S., Llabre, M. & Schneiderman, N., (2006). Reductions in depressed mood and denial coping during cognitive behavioral stress management with HIV-positive gay men treated with HAART. Annals of Behavioral Medicine, 31(2), 155-164.
Penedo, F. J., Dahn, J. R., Shen, B. J., Schneiderman, N., and Antoni, M. H. (2006). Ethnicity and determinants of quality of life following prostate cancer treatment. Urology, 67(5), 1022-1027.
Penedo, F. J., Molton, I., Dahn, J. R., Shen, B. J., Kinsinger, D., Schneiderman, N., & Antoni, M. (2006). A randomized clinical trial of group-based cognitive-behavioral stress management (CBSM) in localized prostate cancer: Development of stress management skills improves quality of life and benefit finding. Annals of Behavioral Medicine, 31(3), 261-270.
Penedo, F. J., Dahn, J., Kinsinger, D., Antoni, M. H., Molton, I., Gonzalez, J .S., Fletcher, M. A., Roos, B., Carver, C. & Schneiderman, N. (2006). Anger suppression mediates the relationship between optimism and natural killer cell cytotoxicity in men treated for localized prostate cancer. Journal of Psychosomatic Research, 60(4), 423-427.
Kinsinger, D., Penedo, F. J., Antoni, M., Dahn, J., Lechner, S., & Schneiderman, N. (2006). Psychosocial and sociodemographic correlates of benefit-finding in men treated for localized prostate cancer. Psycho-Oncology, March 8 [published online]. Retrieved from http://www3.interscience.wiley.com/cgi-bin/fulltext/112475252/PDFSTART
Antoni, M. H., Carrico, A. W., Duran, R. E., Spitzer, S., Penedo, F. J., Ironson, G., Fletcher, M. A., Klimas, N., & Schneiderman, N. (2006). Randomized clinical trial of cognitive behavioral stress management on HIV viral load in gay men treated with HAART. Psychosomatic Medicine, 68(1), 143-151.
Weaver, K., Llabre, M., Durán, R., Antoni, M., Penedo, F. J., Ironson, G., & Schneiderman, N. (2005). A Stress and Coping Model of Medication Adherence and Viral Load in HIV+ Men and Women on Highly Active Antiretroviral Therapy (HAART). Health Psychology, 24(4), 385-392.
Dahn, J. R., Penedo, F. J., Molton, I., Lopez, L., Schneiderman, N., & Antoni, M. H. (2005). Physical activity and sexual functioning after radiation for prostate cancer: Beneficial effects for external beam patient. Urology, 65(5), 953-958.
Penedo, F. J. & Dahn, J. R. (2005). Exercise and well-being: a review of mental and physical health benefits associated with physical activity. Current Opinion in Psychiatry, 18(2), 189-193.
Dahn, J. R., Penedo, F. J., Gonzalez, J. S., Esquiabro, M., Antoni, M. H., Roos, B., & Schneiderman, N. (2004). Sexual functioning and quality of life after prostate cancer treatment: considering sexual desire. Urology, 63(2), 271-275.
Gonzalez, J. S., Penedo, F. J., Antoni, M. H., Duran, R., Fernandez, M. I., McPherson-Baker, S., Ironson, G., Klimas, N., Fletcher, M. A., & Schneiderman, N. (2004). Social support, positive states of mind and HIV treatment adherence in men and women living with HIV/AIDS. Health Psychology, 23, (4), 413-418.
Penedo, F. J. & Dahn, J. R. (2004). Prostate cancer and quality of life: A review and evaluation of the impact of treatment, disease burden and psychosocial interventions. Expert Review of Pharmacoeconomics and Outcomes Research, 4(5), 525-535.
Penedo, F. J., Schneiderman, N., Dahn, J. R., & Gonzalez, J. S. (2004). Physical activity interventions in the elderly: cancer and co-morbidity. Cancer Investigations, 22(1), 51-67.
Weaver, K. E., Antoni, M. H., Lechner, S. C., Duran, R. E., Penedo, F. J., Fernandez, M. I., Ironson, G., & Schneiderman N. (2004). Perceived stress mediates the effects of coping on the quality of life of HIV-positive women on highly active antiretroviral therapy. AIDS Behavior, 8(2), 175-183.
Penedo, F. J., Dahn, J. R., Molton, I., Gonzalez, J., Kinsinger, D., Roos, B., Carver, C. S., Schneiderman, N., & Antoni, M. (2003). Cognitive behavioral stress management improves stress management skills and quality of life in men recovering from prostate cancer. Cancer, 100(1), 192-200.
Penedo, F. J., Dahn, J. R., Gonzalez, J. S., Molton, I., Carver, C. S., Antoni, M. H., Roos, B., & Schneiderman, N. (2003). Perceived stress management skill mediates the relationship between optimism and positive mood following radical prostatectomy. Health Psychology, 22(2), 220-222
Penedo, F. J., Gonzalez, J. S., Dahn, J. R., Antoni, M. H., Malow, R. M., Costa, P. & Schneiderman, N. (2003). Personality, quality of life and HAART adherence among men and women living with HIV/AIDS. Journal of Psychosomatic Research, 54(3), 271-278.
Penedo, F. J., Gonzalez, J. S., Davis, C., Antoni, M. H., Malow, R. M. & Schneiderman, N. (2003). Coping and psychological distress among symptomatic HIV+ men who have sex with men. Annals of Behavioral Medicine, 25(3), 203-213
Cruess, S., Antoni, M. H., Hayes, A., Penedo, F. J., Ironson, G. H, Fletcher, M. A., Lutgendorf, S., & Schneiderman, N. (2002). Changes in mood and depressive symptoms and related change processes during cognitive-behavioral stress management in HIV-infected men. Cognitive Therapy and Research, 26(3), 373-392.
Penedo, F. J., Molton, I., & Schneiderman, N. (2002). Psychosocial interventions in older adults living with HIV/AIDS. Paginas de Psiquiatría (Psychiatric Pages; Spanish), 9, 9-10.
ENRICHD Investigators, Berkman, L. F., Schneiderman, N., Ironson, G. H., Mellman, T., Myerburg, F. J., Penedo, F. J., et al. (2000). Enhancing recovery in coronary heart disease patients (ENRICHD): Study design and methods. American Heart Journal, 139(1), 1-9
McMahon, R., Malow, R. M., & Penedo, F. J. (2001). Psychiatric symptoms and HIV risk in MMPI-2 cluster subgroups of alcohol and other drug abusers. Journal of Addictive Diseases, 20(4), 27-40.
Penedo, F. J., Antoni, M. H., Schneiderman, N., Ironson, G. H., Malow, R. M., Cruess, S., Hurwitz, B., & LaPerriere, A. (2001). Dysfunctional attitudes, coping and depression among HIV+ men who have sex with men (MSM). Cognitive Therapy and Research, 25(5), 591-606.
McPherson-Baker, S., Malow, R. M., Penedo, F. J., Jones, D. L., Schneiderman, N., & Klimas, N. (2000). Enhancing adherence to combination antiretroviral therapy in non-adherent HIV-positive men. AIDS Care, 12, 399-404.
McMahon, R. C., Malow, R. M., & Penedo, F. J. (1998). Substance abuse problems, psychiatric severity, and HIV risk in MCMI-II personality subgroups. Journal of Addictive Behaviors, 12(1), 3-13.
Malow, R. M., McPherson, S., Klimas, N., Antoni, M. H., Schneiderman, N., Penedo, F. J., Ziskind, D. & Page, B. (1998). Alcohol & Drug Abuse: Adherence to complex combination antiretroviral therapies in HIV+ drug abusers. Psychiatric Services, 49, 1021-1024
Malow, R. M., Burns Jager, K., Ireland, S. J., & Penedo, F. J. (1996). HIV infection and risky sexual behaviors among women in treatment for non injection drug dependence. Psychiatric Services, 47(11), 1197-1199.
Lutgendorf, S., Antoni, M. H., Ironson, G. H., Fletcher, M. A., Penedo, F. J., Baum, A., Schneiderman, N., & Klimas, N. (1995). Physical symptoms of chronic fatigue syndrome are exacerbated by the stress of Hurricane Andrew. Psychosomatic Medicine, 57, 310-323.
Courses
PSY342 - Psychology of Adulthood and Aging
The aim of this course is to provide students with a broad overview and introduction to the psychology of aging. Students will be introduced to the major developments during the middle and later years of adulthood including social (e.g., retirement), cognitive (e.g., processing speed declines) and physical (e.g., organ changes, immunosenescence) changes. Basic theoretical models as applied to the biology of aging and psychosocial development in adulthood will be discussed. Research methods and current information on the psychology of aging will be covered and applied to the understanding of older adults.
Links
Aging
Prostate Cancer
HIV/AIDS
Hispanics/Latinos and Cancer
General Research Interest Sites
- Centers for Disease Control
- National Institutes of Health
- National Aging Institute
- National Institute of Mental Health
- National Cancer Institute
Scientific Societies
- American Psychological Association
- Gerontological Society of America
- Society of Behavioral Medicine
- International Society of Behavioral Medicine
- American Psychosomatic Society