Edward J. Green
Edward J. Green, PhD.
Associate Professor University of Illinois, 1985
- Research Interests
- Basic pathomechanisms underlying stroke and head trauma; recovery from neurobehavioral deficits resulting from stroke/head trauma.
- Current Research
- Neuroscience Program
- Selected Publications
- Undergraduate Research Opportunities
- Teaching
Research Interests:
A major focus of my research involves an examination of behavioral indices of recovery following CNS ischemia and head trauma. Current work utilizes animal models in order to evaluate treatments designed to attenuate neural dysfunction resulting from these types of insults. Animal models include the use of rats and gneetically-altered mice (knockout, trangenic). Treatments include those that may either provide neuroprotection from the insults, or facilitate recovery through synaptic re-wiring. At present, we are evaluating the influence of post-insult temperature manipulation and pharmacotherapy, as well as the administration of trophic factors. Behavioral assessment techniques include the quantitative evaluation of sensorimotor integration and cognition (spatial learning/memory). Electrophysiological techniques performed with freely moving or anesthetized animals include the extraction of unit activity from individual cells within a multiunit record, simultaneous recording from several neural loci, and recording stimulus-evoked field potentials.
Other Research Interests: Synaptic mechanisms underlying information storage in the CNS.
Selected Publications
Sanders, M.J., Sick, T.J., Perez-Pinzon, M.A., Dietrich, W.D., Green, E.J. (2000) Chronic failure in the maintenance of long-term potentiation following fluid-percussion injury in the rat, Brain Resarch 861:69-76..
Sanders, M.J., Dietrich, W.D., Green, E.J. (1999) Cognitive function following traumatic brain injury: Effects of injury severity and recovery period in a parasagittal fluid percussive injury model, Journal of Neurotrauma 16:915-925.
Bramlett, H.M., Green, E.J. and Dietrich, W.D (1999) Secondary hypoxia following moderate fluid percussion brain injury in rats exacerbates sensorimotor and cognitive deficits. Journal of Neurotrauma 16: 1035-1047.
Bramlett, H.M., Green, E.J. and Dietrich, W.D (1999) Exacerbation of cortical and hippocampal CA1 damage due to posttraumatic hypoxia following moderate fluid percussion brain injury in rats. Journal of Neurosurgery 91:653-659.
Kao, K., Sanders, M.J., and Green, E.J. (1997) Physiological evidence for hippocampal disinhibition resulting from activation of the median raphe. Brain Research. 752:90-98.
Bramlett, H.M., Kraydieh, S., Green, E.J., and Dietrich, W.D., (1997) Temporal and regional patterns of axonal damage following traumatic brain injury: A beta-amyloid precursor protein immunocytochemical study in rats. Journal of Neuropathology and Experimental Neurology 56:1132-1141.
Bramlett, H.M., Green, E.J., and Dietrich, W.D. (1997) Hippocampally-dependent and independent chronic spatial navigational deficits following parasagittal fluid percussion brain injury in the rat. Brain Research 762:195-202.
Alexis, N., Dietrich, W.D., Prado, R., Green, E. and Busto, R. (1997) The role of nitric oxide in the pathophysiology of thromboembolic stroke in the rat. Brain Research.759:32-40.
Bramlett, H.M., Dietrich, W.D., Green, E.J. and Busto, R. (1997) Chronic histopathological consequences of fluid-percussion brain injury in rats: effects of post- traumatic hypothermia. Acta Neuropath. 93:190-199.
McEchron, M.D., Green, E.J., Winters, R.W., Nolen, T.G., Schneiderman, N. and McCabe, P.M. (1996) Changes of synaptic efficacy in the medial geniculate nucleus as a result of auditory classical conditioning. Journal of Neuroscience.16: 1273-1283.
Green, E.J., Pazos, A.J., Dietrich, W.D., McCabe, P.M., Schneiderman, N., Lin, B., Busto, R., Globus, M.Y.-T., and Ginsberg, M.D. (1995) Combined postischemic hypothermia and delayed MK-801 treatment attenuates neurobehavioral deficits following transient global ischemia in rats. Brain Research 702:145-152.
Alexis, N.E., Dietrich, W.D., Green, E.J. Prado, R. and Watson, B.D. (1995) Non- occlusive common-carotid artery thrombosis (CCAT) in the rat results in reversible sensorimotor and cognitive behavioral deficits. Stroke 26:2238-2346.
Pazos, A.J., Orezzoli, S.L., McCabe, P.M., Dietrich, W.D and Green, E.J., (1995) Recovery of a vibrissae-dependent behavioral response following photothrombotic infarction of the somatosensory cortex in rats. Brain Research 689:224-232.
Dietrich, W.D., Lin, B., Globus, M.Y.-T., Green, E.J., Ginsberg, M. and Busto, R. (1995) Effect of delayed MK-801 (dizocilpine) treatment with or without immediate postischemic hypothermia on chronic neuronal survival after global forebrain ischemia in rats. Journal of Cerebral Blood Flow and Metabolism, 15 (6):960-968.
Bramlett, H. M., Green, E. J., Dietrich, W. D., Busto, R., Globus, M. Y.-T. and Ginsberg, M. D. (1995) Post-traumatic brain hypothermia provides protection from sensorimotor and cognitive behavioral deficits. Journal of Neurotrauma 12: 289-298.
Markgraf, C. G., Green, E. J., McCabe, P.M., Schneiderman, N., Dietrich, W.D., and Ginsberg, M. (1994) Recovery of sensorimotor function following distal middle cerebral artery photothrombotic occlusion in rats. Stroke 25: 153-159.
Green, E.J., Barnes, C.A., and McNaughton, B.L. (1993) Behavioral state dependence of homo- and hetero-synaptic modulation of dentate gyrus excitability. Experimental Brain Research 93: 55-65.
Green, E.J., Dietrich, W.D., vanDijk, F., Busto, R., Markgraf, C.G., McCabe, P.M., Ginsberg, M.D. and Schneiderman, N. (1992) Protective effects of brain hypothermia on histopathology and behavior following global cerebral ischemia in the rat. Brain Research 580: 197-204.
Research Opportunities
Undergraduate students with an interest in Psychobiology/Neuroscience have the opportunity to participate in research with UM faculty, in laboratories situated on the Coral Gables and Medical School Campuses. Many subfields within neuroscience are represented, including neuroanatomy, neuropharmacology, neurophysiology and neurobehavior.
Qualified undergraduates may be eligible to receive Psychology course credit for research participation. Please contact the Psychology faculty member of interest for more information. Students interested in conducting research with non -Psychology faculty should contact Dr. E. Green to discuss this option.
Students may have the opportunity to compete for summer research fellowships. Honors students should contact Andrea Dupuch (284-5384) for further information about the Honors Summer Research Program.
Summer research fellowships for women and minority students are also available through the Arts and Sciences Deans Office (284-4036). Deadlines for these fellowships are in the spring semester.
The National Institutes of Health also offers offers scholarships to qualified undergraduates who are committed to a career in biomedical research.
The following faculty have expressed an interest in working with undergraduate students. Follow the provided link to find out more about the research conducted by each faculty member.
Psychology Faculty
- Edward J. Green, Ph.D. Psychology / Gables Campus/ Behavioral recovery following CNS insults
- Philip M. McCabe, Ph.D.Psychology / Gables Campus/ CNS mechanisms underlying learning
- Steven K. Sutton, Ph.D. Psychology / Gables Campus/ Neurobiology of emotion and personality
Other Faculty *
- John Lu, Ph.D. Biology / Gables Campus/ Neural basis of sound localization
- Dalton Dietrich, Ph.D. Neurol Surgery / Med Campus/ Spinal cord injury mechanisms and recovery
- Mary J. Eaton, Ph.D. Neurol Surgery / Med Campus/ Behavioral recovery after spinal cord injury
- John Hackman, Ph.D. Neurology / Med Campus/ Neurophysiology /pharmacology of spinal cord
- Thomas J. Sick, Ph.D. Neurology / Med Campus/ Pathomechanisms of brain ischemia/anoxia
- Brant Watson, Ph.D. Neurology / Med Campus/ Pathomechanisms of thrombotic stroke
* For information about working with non-Psychology faculty members, please contact:
(305) 284-4186, ext 4